Baseball – Leading Season Strikeouts Record Holders

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Rank Player Strikeouts Year
1 Matt Kilroy 513 1886
2 Toad Ramsey 499 1886
3 Hugh Daily 483 1884
4 Dupee Shaw 451 1884
5 Old Hoss Radbourn 441 1884
6 Charlie Buffinton 417 1884
7 Guy Hecker 385 1884
8 Nolan Ryan 383 1973
9 Sandy Koufax 382 1965
10 Bill Sweeney 374 1884
11 Randy Johnson 372 2001
12 Pud Galvin 369 1884
13 Mark Baldwin 368 1889
14 Nolan Ryan 367 1974
15 Randy Johnson 364 1999
16 Tim Keefe 359 1883
17 Toad Ramsey 355 1887
18 Rube Waddell 349 1904
19 Bob Feller 348 1946
20 Randy Johnson 347 2000
21 Hardie Henderson 346 1884
22 Mickey Welch 345 1884
22 Jim Whitney 345 1883
24 Jim McCormick 343 1884
25 Amos Rusie 341 1890
25 Nolan Ryan 341 1977
27 Amos Rusie 337 1891
27 Charlie Sweeney 337 1884
29 Tim Keefe 335 1888
30 Randy Johnson 334 2002
30 Tim Keefe 334 1884
32 Randy Johnson 329 1998
32 Nolan Ryan 329 1972
34 Nolan Ryan 327 1976
35 Gerrit Cole 326 2019
35 Ed Morris 326 1886
37 Sam McDowell 325 1965
37 Tony Mullane 325 1884
39 Lady Baldwin 323 1886
40 Curt Schilling 319 1997
41 Sandy Koufax 317 1966
42 Curt Schilling 316 2002
43 Old Hoss Radbourn 315 1883
44 Bill Hutchison 314 1892
45 John Clarkson 313 1886
45 Walter Johnson 313 1910
45 Pedro Martínez 313 1999
45 J.R. Richard 313 1979
49 Steve Carlton 310 1972
50 John Clarkson 308 1885
50 Randy Johnson 308 1993
50 Mickey Lolich 308 1971
50 Larry McKeon 308 1884
50 Chris Sale 308 2017
Updated: October 4, 2025
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